Assessment of Variations in PT, APTT and Platelet Count and Their Correlation with Glycated Hemoglobin in Type 2 Diabetes mellitus


  • Sajjad Ahmad Department of Pathology, Quaid-e-Azam Medical College, Bahawalpur, Pakistan.
  • Haji Muhammad Rashid Department of Chemical Pathology, University of Health Sciences, Lahore, Pakistan.
  • Wali Ur Rahman Department of Medical Lab Technology, University of Haripur, Pakistan.
  • Muhammad Mujahid Pathology Department, BSL-3 Lab, DHQ Hospital Sargodha, Pakistan.
  • Hafiz Muhammad Waleed Pathology Department, THQ Hospital, Mianchannu, Pakistan.
  • Whied ul Hussan Shahzad Institute of Industrial Biotechnology, Government College University, Lahore, Pakistan.



Activated Partial Prothrombin Time, Diabetes, HbA1c, Platelet count, Prothrombin Time.


Background: Diabetic patients are at higher risk of cardiovascular disease than non-diabetics. Elevated glucose level in type 2 Diabetes mellitus (T2DM) can induce variations in blood composition and blood vesicles, which lead towards coagulation abnormalities and cardiovascular disease. Prothrombin Time (PT) Activated Partial Thromboplastin Time (APTT) and platelet count are commonly used tests to assess the coagulation abnormalities of blood.

Objectives: To evaluate the variations in PT, APTT and platelet count in T2DM and their correlation with glycated hemoglobin.

Methodology: This cross sectional study was performed at Asia Diagnostic Center, Islamabad. Pre-diagnosed 52 adults with type 2 Diabetes mellitus, from 35 to 65 years of age, and 52 sex and age matched healthy subjects were considered as control in this study. Glycosylated Hemoglobin (HbA1c), APTT, PT and platelet counts were measured in both groups.

Results: PT and APTT were significantly lower in T2DM patients (p value < 0.0001) and platelet count was slightly higher in T2DM (p value = 0.13) than the control group. PT (r2= -0.23) and APTT (r2= -0.16) were negatively correlated with HbA1c, while platelet count was positively correlated with HbA1c (r2=0.23) in T2DM group.

Conclusion: From our study, it was concluded that low PT and APTT with relatively high platelet count in T2DM than control group may induce coagulopathies that can lead toward thrombosis in T2DM patients.