The Biochemical Profile of Chronic Kidney Disease Patients

Authors

  • Afshan Zeeshan Wasti Jinnah University for Women, Karachi
  • Saba Haider Jinnah University for Women, Karachi
  • Shabana Rashid Jinnah University for Women, Karachi
  • Naureen Fatima Jinnah University for Women, Karachi
  • Afshan Ashiq Jinnah University for Women, Karachi
  • Sumaira Iqbal Jinnah University for Women, Karachi

Keywords:

Chronic Kidney Disease (CKD), Lipid profile, Renal profile, Hematological profile

Abstract

Chronic kidney disease-CKD is a major public health problem and cause of morbidity and mortality worldwide. In Pakistani population, the prevalence of CKD is unexpectedly high therefore not unexpected since incidence of hypertension and diabetes in Pakistani population is one of the highest in the world. CKD is defined as impaired glomerular filtration rate (GFR) or elevated albumin excretion in the urine, and has been recognized as an important risk factor contributing to cardiovascular disease and death. The most common risk factors for CKD includes; diabetes mellitus, hypertension, dyslipidemia and most important older age, but the clinical implications still remain uncertain in elderly persons suffering from CKD. The present study aims to evaluate the biochemical profile in the patients with chronic kidney disease as compared to the healthy controls. Analysis of lipid profile (Cholesterol, Total Lipid, HDL-C, LDL-C, and Triglycerides), renal profile (Urea, Creatinine, BUN and Uric acid), Electrolytes (Sodium, Potassium, Chloride and Bicarbonate) and Hematological indices were carried out in CKD patients (n=50) as compared to the healthy individual (n=50) by using Automated and standardized kit methods. We suggests the use of stringent hematological and biochemical testing such as lipid and renal profile in the patients suffering from Chronic kidney disease, for correct diagnosis and more accurate treatment strategy to decrease morbidity and mortality related with CKD.

Author Biographies

Afshan Zeeshan Wasti, Jinnah University for Women, Karachi

Department of Biochemistry

Saba Haider, Jinnah University for Women, Karachi

Department of Botany

Shabana Rashid, Jinnah University for Women, Karachi

Department of Biochemistry

Naureen Fatima, Jinnah University for Women, Karachi

Chronic kidney disease-CKD is a major public health problem and cause of morbidity and mortality worldwide. In Pakistani population, the prevalence of CKD is unexpectedly high therefore not unexpected since incidence of hypertension and diabetes in Pakistani population is one of the highest in the world. CKD is defined as impaired glomerular filtration rate (GFR) or elevated albumin excretion in the urine, and has been recognized as an important risk factor contributing to cardiovascular disease and death. The most common risk factors for CKD includes; diabetes mellitus, hypertension, dyslipidemia and most important older age, but the clinical implications still remain uncertain in elderly persons suffering from CKD. The present study aims to evaluate the biochemical profile in the patients with chronic kidney disease as compared to the healthy controls. Analysis of lipid profile (Cholesterol, Total Lipid, HDL-C, LDL-C, and Triglycerides), renal profile (Urea, Creatinine, BUN and Uric acid), Electrolytes (Sodium, Potassium, Chloride and Bicarbonate) and Hematological indices were carried out in CKD patients (n=50) as compared to the healthy individual (n=50) by using Automated and standardized kit methods. We suggests the use of stringent hematological and biochemical testing such as lipid and renal profile in the patients suffering from Chronic kidney disease, for correct diagnosis and more accurate treatment strategy to decrease morbidity and mortality related with CKD.

Afshan Ashiq, Jinnah University for Women, Karachi

Department of Biochemistry

Sumaira Iqbal, Jinnah University for Women, Karachi

Department of Biochemistry

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Published

2013-01-11