The Biochemical Profile of Chronic Kidney Disease Patients

Abstract

Chronic kidney disease-CKD is a major public health problem and cause of morbidity and mortality worldwide. In Pakistani population, the prevalence of CKD is unexpectedly high therefore not unexpected since incidence of hypertension and diabetes in Pakistani population is one of the highest in the world. CKD is defined as impaired glomerular filtration rate (GFR) or elevated albumin excretion in the urine, and has been recognized as an important risk factor contributing to cardiovascular disease and death. The most common risk factors for CKD includes; diabetes mellitus, hypertension, dyslipidemia and most important older age, but the clinical implications still remain uncertain in elderly persons suffering from CKD. The present study aims to evaluate the biochemical profile in the patients with chronic kidney disease as compared to the healthy controls. Analysis of lipid profile (Cholesterol, Total Lipid, HDL-C, LDL-C, and Triglycerides), renal profile (Urea, Creatinine, BUN and Uric acid), Electrolytes (Sodium, Potassium, Chloride and Bicarbonate) and Hematological indices were carried out in CKD patients (n=50) as compared to the healthy individual (n=50) by using Automated and standardized kit methods. We suggests the use of stringent hematological and biochemical testing such as lipid and renal profile in the patients suffering from Chronic kidney disease, for correct diagnosis and more accurate treatment strategy to decrease morbidity and mortality related with CKD.