Detection of Du Antigen in Rh Negative Blood Group Individuals

Authors

  • Naheed Afshan1 1Department of Microbiology,

Keywords:

Agglutination, Blood group, Du antigen, Rh antigen, Serum

Abstract

Du is the weak expression of D antigen. The cells which are not immediately agglutinated by Anti-D
sera cannot be easily classified as D negative because some of these agglutinate after addition of
antiglobulin sera. This weak reactivity is termed as Du. Du positive cells are likely to elicit an immune
response in D negative individuals and the Du cells could be destroyed if the recepient is already
immunized. Therefore, Du positive donor is treated as D positive and recipient is treated as negative.
This report is based on Du antigen and the testing of Du antigen. In this report we discussed about
the detection of Du Antigen using 2 different protocols that show how to test the presence and absence
of Du antigen in Rh negative blood group individuals. In this study we included 100 blood group Dnegative
individuals .The result showed there were 3% that have Du antigen in their blood.

Author Biography

Naheed Afshan1, 1Department of Microbiology,

Jinnah University for Women, Karachi -74600, Pakistan

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Published

2013-04-14

Issue

Vol. 4 No. 2 (2013): Volume 4 (2), July 2013

Section

Articles

License

Creative Commons License
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.