Review Effect of Caffeine Overdose

  • Zaheer Ahmed Chandio Department of Chemistry, Shaheed Benazir Bhutto University, Shaheed Benazirabad, Pakistan
  • Aaisha Sidiqua Department of Chemistry, Shaheed Benazir Bhutto University, Shaheed Benazirabad, Pakistan
  • Mazhar Iqbal Khaskheli M. A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, Pakistan
  • Amrat Waghani Department of Chemistry, Shaheed Benazir Bhutto University, Shaheed Benazirabad, Pakistan
  • Wazir Ali Metlo Department of Molecular Biology and Genetics, Shaheed Benazir Bhutto University, Shaheed Benazirabad, Pakistan
Keywords: Caffeine, Beverages, Headache, Fatigue, Insomnia, Anxiety

Abstract

Background: Caffeine is from methyl xanthine class which mainly stimulates the central nervous system. Caffeine is one of the most widely used psychoactive drugs in the world. It is commonly found in beverages, chocolates, cocoa containing products and in medications. Caffeine is recognized as legal and its consumption is unregulated all over of the world.

Objectives: The objective of this study is to summarize the impact of caffeine on behavioral and health alterations, in both controlled and overdose conditions. Moreover, the specifics of caffeine withdrawal and a number of guidelines on how to handle reducing or quitting caffeine intake altogether is also highlighted.

Methodology: To compose this review, more than seventy research and review articles were overviewed that were published over a period of last twenty years, using Google Scholar search engines.

Results: Caffeine regular use causes physical dependence which may become the caffeine withdrawal sign that can consequently harm normal working. The most important function of caffeine is that it can reversibly blocks the adenosine performance on its receptor and as a result which prevent the beginning of drowsiness encouraged by adenosine. Caffeine also stimulates certain portions of the autonomic nervous system symptom including fatigue, drowsiness, depressed mood, headache, difficulty concentrating, decreased energy, decreased contentedness, decreased alertness, irritability and unclear headed.

Conclusion: It is concluded that utilization of caffeine in a prescribed dose can have good impact on health and may decrease addictive symptoms. Additionally, reducing caffeine dosage over a six-week period guides to successful, long-term caffeine cessation with very few side effects.

Published
2021-01-27